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Japan's experience suggests that there is unmet potential for lower-risk products that could be realized with smarter policy, but advocates of harm reduction are divided on what that should entail

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Assessing the lung cancer risk reduction potential of cMRTPs before or soon after they are introduced into the market is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon smoking cessation and a fortiori upon switching to a cMRTP

Recognizing that bootleggers were redistilling industrial alcohol to make it potable, the government poisoned the supply to render it irreversibly toxic

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